Ohtsuki, Gen

Gen Ohtsuki is a program-specific Professor at Kyoto University Graduate School of Medicine. He graduated as a B.S., Kyoto University, Japan (2002) and received his Ph.D. in 2007 from Kyoto University Graduate School of Science, Japan, which was followed by postdoctoral researches at Erasmus University Medical Center, Department of Neuroscience, the Netherlands (2007-2008) and at the University of Chicago, Department of Neurobiology, USA (2008-2011). From 2006 to 2007, he received the researcher fellowship for Young Scientists of JSPS. He worked as a program-specific Assistant professor at Kyushu University, Graduate School of Medical Sciences, Japan (2011 to 2015). Then, he joined the Hakubi-project (Kyoto University) as an independent program-specific Associate Professor (2015 to 2020) and moved to Kyoto University Graduate School of Medicine in 2020.


He revealed several forms of the plasticity in the cerebellar Purkinje cells at developmental climbing-fiber synapses, firing increase plasticity and associated changes, and excitability plasticity of the dendrites (Ohtsuki & Hirano, 2008 EJN: Ohtsuki et al., 2012b Neuron; Ohtsuki & Hansel, 2018 iScience). Further, he found the compartmentalization and clustering modulation of synaptic input on dendrites (*Ohtsuki, 2020, J Neurosci). In the visual cortex, using the multi-photon imaging system, he revealed the similarity in the visual function among clonally-related neurons (Ohtsuki et al., 2012a Neuron). He has also found the mechanisms of the acute inflammation-triggered plasticity in the cerebellum, and modulation of the behavior and brain activity, which was recovered by the suppression of aberrant immunity via microglia (Yamamoto et al. / *Ohtsuki, 2019 Cell Rep). Current his research is focused on cerebellar involvement of higher-order cognitions and the relevance to psychiatric diseases from the view of Neuroscience, Neuropharmacology, Drug discovery research.


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Asia Research News


Press Conference Abstract in the Society for Neuroscience

(2019 October 19-23rd, Neuroscience 2019, Chicago, USA). “Self-Sabotage: The Role of the Immune System in Neurological Disorders.”

Ohtsuki, Gen

  1. SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells.*Ohtsuki G, Piochon C, Adelman JP, Hansel C.Neuron, Volume 75, Issue 1, 108-120; 12 Jul 2012, doi: 10.1016/j.neuron.2012.05.025
  2. Similarity of visual selectivity among clonally related neurons in visual cortex.*Ohtsuki G, *Nishiyama M, *Yoshida T, Murakami T, Histed M, Lois C, Ohki K.Neuron, Volume 75, Issue 1, 65-72; 12 Jul 2012, doi: 10.1016/j.neuron.2012.05.023
  3. Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation.*Yamamoto M, *Kim M, *Imai H, Itakura Y, †Ohtsuki G.Cell Reports, Volume 28, 2923-2938.e8. 10 Sep 2019, doi: 10.1016/j.celrep.2019.07.078 (This study was selected to the Press Conference Abstract in the Society for Neuroscience, USA, in Chicago, October 19-23rd, Self-Sabotage: The Role of the Immune System in Neurological Disorders)
  4. Modification of synaptic-input clustering by intrinsic excitability plasticity on cerebellar Purkinje cell dendrites.*†Ohtsuki G.Journal of Neuroscience, Volume 40, 267-282; 8 Jan 2020, doi: 10.1523/JNEUROSCI.3211-18.2019


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